Drug metabolism studies

DMPK

ADME testing PK/PD studies

Home . Discovery Services . DMPK . Drug metabolism studies

Drug metabolism studies, a key analysis for drug development

Drug metabolism studies are crucial in drug discovery, it allows to examine how a drug is metabolized, identify metabolites, and assess pharmacokinetics and safety. By using ADME/DMPK assays throughout the process, these studies provide insights into drug efficacy and immunogenicity, helping optimize and de-risk compounds cost-effectively.

Schema Drug discovery journey_Drug Metabolism studies

Drug metabolism studies throughout the drug discovery journey

Oncodesign Services’ platforms offer advanced techniques to investigate drug candidates’ safety and efficacy, providing critical data that accelerates research and streamlines the path from discovery to the clinic.

A wide range of drug metabolism studies performed by Oncodesign Services

Drug metabolism studies encompasses a variety of protocols and techniques aimed at thoroughly predicting how a drug will behave within biological systems, including how it is absorbed, distributed, metabolized, and excreted. These studies help in identifying, and understanding, early stability issues and potential toxicity that are critical for the drug development and thus reducing the risk of late-stage failures.

1. Sample Collection and Preparation
2. Analytical Techniques (HPLC, UPLC, LC-MS)
3. Identification of Metabolites (MS/MS, NMR)
4. Quantification
5. Pharmacokinetic Analysis (half-life, clearance, bioavailability)
6. ADME testing (cross-species PK, In vivo enzyme-mediated metabolism & transporters induction/down-regulation (MS2plex® technique) or inhibition activity measurement)
7. Metabolic Pathway Elucidation
8. Data Interpretation & Regulatory Compliance

Need for drug metabolism studies? Contact-us!

Lastname*

Firstname*

Company

Email*

Phone

Country

Message

I agree to receive e-mail communications from Oncodesign Services and associated companies, and I authorize the storage and processing of my information for any follow-up requests to identify potential products or services that meet my needs.

I authorize the storage and processing of my information for any follow-up requests to identify potential products or services that meet my needs. You can unsubscribe from our communication campaigns at any time. For information on the right to the protection of personal data in accordance with European legislation, consult our privacy policy. ***

* Required