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Authors:
Nicolas S George, Marharyta Kosiuha, Alexandre Moquette, Christophe Parsy (Oncodesign Services)
Abstract:
We describe herein a versatile methodology for the synthesis of 1,2-sulfoximidoyl ethanols thanks to a Ca(NTf2)2-catalyzed epoxide ring-opening with NH sulfoximines in 2-MeTHF at 90 °C. The reaction is regioselective by an attack on the less hindered position of the epoxides. The chemoselectivity is assessed by competition reactions with others nucleophiles.
Ref :
EurJOC, 2022, https://doi.org/10.1002/ejoc.202201219