Lung models - Oncodesign Services

Lung models

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Preclinical CRO Services for Inflammatory Lung Diseases

 

Acute and chronic inflammatory lung diseases are among the most common medical conditions in the world. Rodent models of lung inflammation are helpful to decipher the mechanisms underlying the triggering and/or sustaining of the disease observed in patients.

Oncodesign Services offers several preclinical models available as CRO services, addressing a variety of lung diseases, and provides CRO support for the de novo development of new lung inflammation models recently described in literature.

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Typical readouts for lung inflammation

  • Body weight
  • Lung weight
  • Lung weight-to-body weight ratio
  • Clinical scoring
  • Edema
  • Fibrosis score
  • Mucus production
  • Viral load
  • Ex vivo lung function, including compliance and elasticity (FlexiVent, SCIREQ)
  • Broncho-alveolar fluid (BALF) cell count and cytokine secretion
  • CT scan
  • Gene expression in lungs, by qPCR/dPCR
  • Biomarker / drug monitoring

 

Common drug administration routes (PO, IV, IP) and also non-typical drug administration routes used for lung therapies:

  • Intra-tracheal
  • Intra-nasal
  • Osmotic mini-pumps

 

Discover Oncodesign Services offers for lung inflammation diseases

Case studies for lung inflammation