CRO services to suppport your Preclinical Development from Target to IND
Preclinical development services have a vital role in the research and development (R&D) of new drugs. Activities that are part of the preclinical development stages are used to test drugs in in vitro and in vivo laboratories to establish the safety profile prior to be in human. Reliability and safety testing of new drugs are paramount, and employing an experienced company to provide preclinical development services can be highly valuable.
Oncodesign Services, a CRO (Contract Research Organization) specializing in drug discovery and preclinical services, supports companies in preclinical development programs.
What is a Preclinical Development?
Preclinical development is an umbrella term that includes any and all activities pharmaceutical companies carry out in drug discovery to ensure the drug is ready for human clinical trials. These activities may also be referred to as preclinical research or preclinical testing.
During preclinical studies, scientists will test a new chemical entity (either small-molecule or biologics), medical treatment or procedure in in-vitro and in-vivo laboratories to determine the efficacity towards the target and including potential side effects. Scientists will also carry out feasibility testing and drug safety assessments to meet the goals of preclinical trials.
According to the results, scientists can work to eliminate or reduce the side effects of the drug or discard any drugs to bring the project to the clinical step.
Which Preclinical Discovery and Development Services are available at Oncodesign Services ?
Our range of preclinical services is provided across all three of our sites (Dijon, Paris and Montreal), with experienced multi-disciplinary teams. We offer preclinical oncology, inflammation and infectious diseases services and can also support microbiome studies. Regardless of research program, companies can choose from services that include lead optimization and preclinical development as integrated (INPACT) or stand-alone (SOLO) programs.
Our teams work together to deliver high-quality scientific results taking into account the target product profile. Below, we have listed the sections and included a few of the preclinical services:
1
Medicinal chemistry
Medicinal Chemistry
Medical Chemistry includes synthetic organic, computational chemistry, Fragment-Based Drug Discovery / Structure-Based Drug discovery, heterocyclic chemistry, boron chemistry for reversible covalent binders, targeted protein degradation, and physical chemistry drive lead optimization.
2
In vitro biology
In vitro biology
Assay development and Medium throughput screening and customized in vitro assays including biochemical, cell-based assays, phenotypic and complex screening
3
DMPK
4
Bioanalysis, , immunogenicity and biomarkers
5
In Vivo pharmacology
In vivo pharmacology
Proof of concept (PoC) pharmacology, efficacy and mechanism of action studies with large selection of rodent models including syngeneic, CDX, PDX, humanised models, and inflammatory disease models, and expertise in wide range of readouts including tumor regression, survival, clinical scoring, biomarker and target validation/engagement, flow cytometry, immuno-histochemistry, and ex vivo functional analysis
Medicinal Chemistry
Medical Chemistry includes synthetic organic, computational chemistry, Fragment-Based Drug Discovery / Structure-Based Drug discovery, heterocyclic chemistry, boron chemistry for reversible covalent binders, targeted protein degradation, and physical chemistry drive lead optimization.
In vitro biology
Assay development and Medium throughput screening and customized in vitro assays including biochemical, cell-based assays, phenotypic and complex screening
In vivo pharmacology
Proof of concept (PoC) pharmacology, efficacy and mechanism of action studies with large selection of rodent models including syngeneic, CDX, PDX, humanised models, and inflammatory disease models, and expertise in wide range of readouts including tumor regression, survival, clinical scoring, biomarker and target validation/engagement, flow cytometry, immuno-histochemistry, and ex vivo functional analysis
Supporting your Preclinical Development Projects with D-VLOP
Our offer D-VLOP supports companies to define and implement pre-clinical strategic programs in line with the requirements of regulatory authorities. Our preclinical development services have been designed for all types of modalities from small molecules, theranostics and biological entities as integrated or SOLO projects.
Who is Oncodesign Services ?
Oncodesign Services is a leading CRO specializing in drug discovery and preclinical services in oncology and immuno-inflammation. The company has world-renowned expertise in preclinical discovery services to accelerate the discovery and development of therapeutic solutions for cancer and other serious diseases.
Working with us will ensure you have access to an extensive platform of discovery capabilities and innovative technologies.
Learn more on our activities ? Contact-us !
